临床药学教研室自2014年成立以来，依托于遵义医科大学扶持学科-临床药学和遵义市临床药学重点实验室两大科研平台积极开展科学研究，促进科教融合。研究方向之一：临床药学基础研究，本研究方向从临床用药问题出发开展临床药学基础研究，重点研究基于临床用药问题的生物药剂学、药动学及其他药学基础课题。研究方向之二：医疗机构药事管理，本研究方向结合临床实践开展临床药学应用研究，重点研究合理用药实践与医疗机构药事管理有关课题。
| 临床药学教研室承担的主要科研项目一览表（2014.01-至今） |
| 序号 |
项目、课题名称（下达文件编号或项目编号） |
来源 |
起讫时间 |
承担人（*） |
合同经费（万元） |
财务到账经费（万元） |
| 1 |
基于自组装短肽纳米纤维水凝胶的HepaRG细胞三维共培养体系构建及其在药物代谢研究中的应用（32160225） |
国家自然科学基金 |
2022.01-2025.12 |
唐富山（1/7） |
36 |
36 |
| 2 |
用于骨结核的PLGA微球自组装短肽水凝胶载药系统构建及初步体外药效学究（gzwkj2023-235） |
贵州省卫生健康委员会 |
2022.08-2024.12 |
唐富山（1/6） |
2 |
2 |
| 3 |
基于肠道微生物-NLRP3炎症小体-色氨酸代谢途径研究金银花多糖改善抑郁作用及机制 |
国家自然科学基金 |
2023.01-2026.12 |
刘萍（1/7） |
34 |
34 |
| 4 |
金银花多糖调控“微生物-肠道-炎性体-脑”作用轴改善小鼠抑郁机制研究 |
贵州省科学技术厅 |
2022.04-2025.03 |
刘萍（1/6） |
10 |
10 |
| 3 |
穗花杉双黄酮通过NLRP3炎症小体介导的巨噬细胞极化抗动脉粥样硬化的作用及机制研究 |
贵州省科学技术厅 |
2022.04-2025.03 |
朱蕾（1/6） |
10 |
10 |
| 4 |
穗花杉双黄酮对Ox-LDL诱导的巨噬细胞焦亡的作用及机制初探 |
贵州省卫生健康委员会 |
2021.08- 2023.12 |
朱蕾（1/5） |
2 |
1 |
| 5 |
基于Nrf2/ARE信号通路探讨绿原酸酰胺类似物对PC12细胞氧化应激损伤的保护机制 |
遵义市科技局 |
2020.10- 2023.10 |
朱蕾（1/4） |
2 |
2 |
| 6 |
靶向SGLT1/2 的双功能孪药设计、合成及抗糖尿病心肌病的作用研究 |
贵州省科学技术厅 |
2022.04-2025.03 |
黄强（1/6） |
10 |
10 |
| 7 |
离子互补型纳米自组装短肽与水难溶性药物的相互作用与控释研究(31460246) |
国家自然科学基金 |
2015.01-2018.12 |
唐富山（1/7） |
48 |
48 |
| 8 |
探针药物法测定小柴胡汤对大鼠CYP3A的影响(黔科合J字{2013}2323) |
贵州省科学技术基金 |
2013.01-2016.12 |
唐富山（1/5） |
3.7 |
3.7 |
| 9 |
基于短肽自组装构建疏水性药物的胶体混悬液-水凝胶给药系统(黔科合LH字[2014]7564号) |
贵州省科学技术基金 |
2014.12-2017.6 |
唐富山（1/5） |
4 |
4 |
| 10 |
基层医疗卫生机构药事管理政策研究 |
国家卫生计生委药政司委托研究课题 |
2015.3-2015.10 |
唐富山（4/9） |
9 |
4.5 |
| 11 |
反应性代谢物的半胱氨酸加合物质谱分析及其与肝毒性关联度研究（黔科合LH字[2015]7546号） |
贵州省科技厅，遵义医学院 2015 年度三方 合作协议项目 |
2015.10-2018.10 |
潘虹 |
5 |
5 |
| 12 |
基于体内过程的淫羊藿总黄酮抗骨质疏松活性成分识别研究 |
贵州省中医药管理局中医药、民族医药科学技术研究课题 |
2015.10-2016.09 |
潘虹 |
0 |
0 |
| 13 |
凤冈锌硒茶中硒元素在大鼠体内的组织分布研究 |
遵义医学院2015年校内自然招标课题 |
2016.01-2016.12 |
潘虹 |
5 |
5 |
| 14 |
凤冈锌硒茶的富硒强化和保健功能研究-凤冈锌硒茶中硒元素在大鼠体内的组织分布 |
贵州省科技厅社会攻关计划 |
2017.01-2019.12 |
潘虹 |
5.0 |
5.0 |
| 15 |
基于代谢处置的京尼平苷肝毒性化学机制研究 |
遵义市科技局-遵义医学院联合基金 |
2017.10-2019.10 |
潘虹 |
4 |
4 |
| 16 |
金银花多糖对乙醇成瘾记忆的调节作用及机制研究 |
贵州省教育厅青年科技人才成长项目 |
2018.01-2021.12 |
刘萍 |
6 |
6 |
| 17 |
遵义市临床药学重点实验室 |
贵州省科技厅、遵义市科技局联合平台项目 |
2015-2021 |
唐富山 |
50 |
50 |
| 18 |
新型吲嗪类化合物的合成及药效学初步评价 |
遵义医科大学博士科研启动基金 |
2020-2022 |
黄强 |
10 |
10 |
| 19 |
金银花提取物对D-半乳糖模型和LPS模型小鼠认知障碍的改善作用及机制探究 |
遵义医科大学博士科研启动基金 |
2019-2022 |
朱蕾 |
10 |
10 |
代表性论文
1. Chengchen Yin, Xing He, Kaili Shen, Xingrui Mu, Fushan Tang*. Knowledge and Behavior in Rational Drug Use Among College Students in Zunyi City. Risk Management Healthcare Policy. 2022,15:121-131.
2. Weipeng Wei, Jianhua Tang, Lei Hu, Yujie Feng, Hongfang Li, Chengchen Yin, Fushan Tang*. Experimental anti-tumor effect of emodin in suspension - in situ hydrogels formed with self-assembling peptide. Drug Delivery. 2021, 28(1):1810-1821.
3. Hongfang Li, Yunyan Tang, Weipeng Wei, Chengchen Yin, Fushan Tang*. Effects of Xiaochaihu decoction on the expression of cytochrome P450s in rats. Experimental and Therapeutic Medicine. 2021, 21(6):588.
4. Hongfang Li, Yunyan Tang, Weipeng Wei, Chengchen Yin, Fushan Tang*. Effects of saikosaponin-d on CYP3A4 in HepaRG cell and protein-ligand docking study. Basic and Clinical Pharmacology and Toxicoogyl. 2021, 128(5):661-668.
5. Weipeng Wei, Jianhua Tang, Hongfang Li, Yongsheng Huang, Chengchen Yin, Dan Li*, Fushan Tang*. Antitumor Effects of Self-Assembling Peptide-Emodin in situ Hydrogels in vitro and in vivo. International Jounal of Nanomedicine. 2021, 16: 47-60.
6. Weipeng Wei , Hongfang Li, Chengchen Yin, Fushan Tang*. Research progress in the application of in situ hydrogel system in tumor treatment. Drug Delivery. 2020, 27(1):460-468.
7. Ting Zhang, Chengchen Yin, Yongchen Geng, Yan Zhou, Shusen Sun, Fushan Tang*. Development and Validation of Psychological Contract Scale for Hospital Pharmacists. Journal of Multidisciplinary Healthcare. 2020, 13:1433-1442.
8. Xingrui Mu, Chengchen Yin, Xing He, Hongfang Li, Yuansha Gong, Weipeng Wei, Yan Zhang, Fushan Tang*. Correlation Between Patients' Medication Adherence and Their Psychological Contract with Hospital Pharmacists. Patient Preference and Adherence. 2020, 14: 1605-1613
9. Jing Zhang, Chengchen Yin, Hongfang Li, Weipeng Wei, Yuansha Gong, Fushan Tang*. Application of Once-Monthly Self-Reported ACT Questionnaire in Management of Adherence to Inhalers in Outpatients with Asthma. Patient Prefererence and Adherence. 2020, 14: 1027-1036.
10. Ping Liu, Hengyan Shen, Qiaoyue Zhang, Limei Zhou, Xinyu Bai and Tao Zhang,Inhibition of reinstatement of alcohol-induced conditioned place preference in mice by Lonicera japonica polysaccharide Food & Function, 2022, 13(16): 8643-8651.
11. Xin-Yu Bai, Ping Liu, Yee-Wen Chai,Yan Wang, Shuang-Hua Ren, Ying-Ying Li, Hong Zhou*, Artesunate attenuates 2, 4-dinitrochlorobenzene-induced atopic dermatitis by down-regulating Th17 cell responses in BALB/c mice[J]. European journal of pharmacology, 2020, 874: 173020.
12. Ping Liu, Lei Zhu, Limei Zhou, Xinyu Bai*, e5NT inhibitor protects acute restraint stress-induced depression by regulating nucleoside release in mice. Journal of Pharmacy and Pharmacology, 2020, 72(11): 1556-1563.
13. Ping Liu, Ping Yang, Lan Zhang. Mode of action of Shan-Zhu-Yu (Cornus officinalis Sieb. et Zucc.) in the treatment of depression based on network pharmacology. Evidence-Based Complementary and Alternative Medicine, 2020.
14. Weipeng Wei, Cui Meng,Yuhe Wang, Yongsheng Huang, Wenbin Du, Hongfang Li, Yanfei Liu, Hong Song, Fushan Tang. The interaction between self - assembling peptides and emodin and the controlled release of emodin from in-situ hydrogel. Artificial cells, nanomedicine and biotechnology, 2019
15. Cui Meng, Weipeng Wei, Yuhe Wang, Kunqin Zhang, Ting Zhang, Yunyan Tang, Fushan Tang. Study on the interaction between self-assembling peptide and mangiferin and in vitro release of mangiferin from in-situ hydrogel. International journal of nanomedicine，2019.
16. Fushan Tang, Yunzhu Han, Guohui Cai, et al. Self-assembling peptide RADA16-I hydrogel for three-dimensional culture of hepatocarcinoma HepG2 cells. International journal of clinical and experimental medicine, 2016.
17. Xinyu Bai, Yuangui Liu, Wu Song, Yingying Li, Dongshun Hou, Haoming Luo, and Ping Liu*, Anticancer activity of tetrandrine by inducing pro-death apoptosis and autophagy in human gastric cancer cells, Journal of Pharmacy and Pharmacology, 2018, 70(8):1048-1058
18. Xiaohang Che, Ping Liu, Chunfu Wu, Wu Song, Nina An, Lisha Yu,Yijun Bai, Zheng Xing, Jialing Cai, Xiaomin Wang, JingyuYang*, Potential role of the ecto-5′-nucleotidase in morphine-induced uridine release and neurobehavioral changes, Neuropharmacology, 2018, 30;141:1-10
19. Ping Liu#, Xiaohang Che#, Lisha Yu, Xiaofeng Yang, Nina An, Wu Song, Chunfu Wu*, Jingyu Yang*, Uridine attenuates morphine-induced conditioned place preference and regulates glutamate/GABA levels in mPFC of mice, Pharmacology, Biochemistry and Behavior, 2017, 163:74-82
20. Hong Pan, Feng Yang, Daiyuan Xiang, Fuguo Shi*. Simultaneous quantification of atractyloside and carboxyatractyloside in rat plasma by LC-MS/MS: Application to a pharmacokinetic study after oral administration of Xanthii Fructus extract, J Sep Sci, 2019.1-8, DOI: 10.1002/jssc.201900888
21. Hong Pan, Yi Li, Linyan Huang, Xumei Zhou, Yuanfu Lu*, Fuguo Shi*. Development and validation of a rapid LC-MS/MS method for the simultaneous quantification of arecoline and its two active metabolites in rat plasma and its applicaiton to a pharmacokinetic study, Journal of Pharmaceutical and Biomedical Analysis, 154 (2018) 397–403
22. Hong Pan, Linyan Huang, Yi Li, Xumei Zhou, Yuanfu Lu*, Fuguo Shi*. Liquid chromatography-tandem mass spectrometric assay for determination of unstable arecoline in rat plasma and its application, Journal of Chromatography B, 2017, 1070: 112-116.
23. Lei Zhu, Zhen Zhang, Xiao-jie Hou, Yong-feng Wang, Jing-yu Yang and Chun-fu Wu. "Inhibition of PDE5 attenuates streptozotocin-induced neuroinflammation and tau hyperphosphorylation in a streptozotocin-treated rat mode." Brain Research 1722(2019).
24. Qiang Huang, Kaikai Dong, Wenjing Bai, Dong Yi, Jian-Xin Ji* and Wei Wei* Org. Lett. 2019, 21, 9, 3332-3336.
25. Qiang Huang, Lei Zhu, Dong Yi, Wei Wei*. Chin. Chem. Lett., 2019, Pages Ahead of Print.
26. 汤云燕，张婷，谌雅丽，肖政，汪成琼，唐富山. 清胰汤对胆源性胰腺炎治疗价值的Meta分析. 遵义医科大学学报，2019.
27. 张婷，耿永晨，周艳，唐富山. 医疗机构药师职业倦怠与其药学服务态度及行为的相关性研究.中国医院管理，2019.
28. 李洪芳,孙树森,张涛, 唐富山.HepaRG细胞在药物代谢相关研究中的应用进展.医药导报,2019.
29. 原凌燕,胡开进,张婷,肖政,汪成琼,唐富山.柴胡舒肝散治疗常见病毒性肝炎的疗效及安全性.基因组学与应用生物学,2019.
30. 汤云燕,兰雪,尚德翠,唐富山.小柴胡汤与化学药联合应用及两者相互作用的研究概况.中国药房,2019.
31. 原凌燕,贺云,汤云燕,唐富山.表没食子儿茶素没食子酸酯对早期压疮大鼠模型缺血再灌注损伤的保护作用及NLRP3炎症小体相关机制研究.中药药理与临床,2019.
32. 唐富山.内布拉斯加大学医学中心药学博士项目培养模式对我国药学教育的启示.中国药房,2018.
33. 唐富山,原凌燕,潘虹,杨成莉,孔晶.对药动学虚拟实验教学的评价与思考.药学教育,2018.
34. 刘萍，白鑫宇*，何泽祝，加味五味石膏汤对卵清蛋白致小鼠变应性鼻炎的作用，中药药理与临床, 2018, 34(2): 1 ~ 4
35. 刘萍，李京*，白鑫宇，五味石膏汤加减治疗过敏性鼻炎的疗效及其对 IgE、EOS、ECP 的影响，辽宁中医杂志，2018, 45(5): 970~973
36. 刘萍，唐富山*，朱燕，徐昆燕，王志敏，槲皮素对PM 2.5导致支气管上皮细胞炎症的保护作用，中药药理与临床, 2017, 33(1): 22 ~ 26
37. 刘萍，白鑫宇，杨帆，张珣，宋伍*，补阴消郁汤配方颗粒对更年期小鼠抑郁的抑制作用研究，中药药理与临床, 2017, 33(1): 158 ~ 161
